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Symbol Name ID |
Cxcr4
C-X-C motif chemokine receptor 4 MGI:109563 |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased circulating IgG level |
Monoclonal immunoglobulin M proteinemia |
Polyclonal elevation of IgM |
Decreased circulating antibody level |
Epistaxis |
Gingival bleeding |
Gastrointestinal hemorrhage |
Retinal hemorrhage |
Purpura |
Abnormal bone marrow cell morphology |
Myelokathexis |
Bone marrow hypercellularity |
Normocytic anemia |
Neutropenia |
Impaired lymphocyte transformation with phytohemagglutinin |
Abnormality of neutrophils |
Leukemia |
Acute myeloid leukemia |
Hypercoagulability |
Lymphoma |
Elevated erythrocyte sedimentation rate |
Splenomegaly |
| Disease(s) Associated with CXCR4 | ||||||||||||||||||||||
| acute myeloid leukemia | ||||||||||||||||||||||
| lymphoplasmacytic lymphoma | ||||||||||||||||||||||
| WHIM syndrome |
| Mouse Phenotypes | decreased B cell apoptosis |
abnormal leukocyte migration |
abnormal thymus morphology |
decreased thymocyte number |
enlarged spleen |
abnormal leukopoiesis |
abnormal lymphopoiesis |
abnormal B cell differentiation |
decreased immature B cell number |
decreased pro-B cell number |
abnormal T cell differentiation |
decreased double-positive T cell number |
failure of myelopoiesis |
impaired myelopoiesis |
decreased bone marrow cell number |
increased neutrophil cell number |
abnormal neutrophil morphology |
decreased mature B cell number |
decreased B-1 B cell number |
decreased B-2 B cell number |
decreased plasma cell number |
increased mature B cell number |
decreased B cell number |
decreased NK cell number |
increased NK cell number |
abnormal CD4-positive, alpha-beta T cell number |
decreased CD4-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
decreased T cell number |
increased lymphocyte cell number |
abnormal macrophage cell number |
increased monocyte cell number |
decreased leukocyte cell number |
increased leukocyte cell number |
abnormal spleen morphology |
decreased spleen weight |
abnormal spleen white pulp morphology |
abnormal B cell physiology |
increased IgG level |
increased IgM level |
decreased immunoglobulin level |
increased immunoglobulin level |
abnormal NK cell physiology |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||
| Cxcr4tm1Qma/Cxcr4tm1Qma | ||||||||||||||||||||||||||||||||||||||||||||
| Cxcr4tm1Tng/Cxcr4tm1Tng | ||||||||||||||||||||||||||||||||||||||||||||
| Cxcr4tm1Yzo/Cxcr4tm1Yzo | ||||||||||||||||||||||||||||||||||||||||||||
| Cxcr4tm3.1Yzo/Cxcr4tm3.1Yzo | ||||||||||||||||||||||||||||||||||||||||||||
| Cxcr4em1(IMPC)Mbp/Cxcr4+ | ||||||||||||||||||||||||||||||||||||||||||||
| Cxcr4tm1.1Bala/Cxcr4+ | ||||||||||||||||||||||||||||||||||||||||||||
| Cxcr4tm1Yiw/Cxcr4tm1Yiw Tg(Lck-cre)1Jtak/0 (conditional) |
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| Cxcr4tm2Yzo/Cxcr4tm2Yzo Cd19tm1(cre)Cgn/Cd19+ (conditional) |
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| Cxcr4tm2Yzo/Cxcr4tm2Yzo Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
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| Cxcr4tm2Yzo/Cxcr4tm2Yzo Tg(Fabp4-cre)1Rev/0 (conditional) |
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| Cd19tm1(cre)Cgn/Cd19+ Cxcr4tm1Tng/Cxcr4tm2Tng (conditional) |
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| Cxcr4tm2Yzo/Cxcr4tm3.1Yzo Cd19tm1(cre)Cgn/Cd19+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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